About: Generation of Antibody Diversity     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Generation of Antibody Diversity
rdfs:subClassOf
Semantic_Type
  • Molecular Function
Preferred_Name
  • Generation of Antibody Diversity
UMLS_CUI
  • C1517502
Legacy_Concept_Name
  • Generation_of_Antibody_Diversity
FULL_SYN
  • Generation of Antibody DiversityPTNCI
DEFINITION
  • Generation of Antibody Diversity during B-lymphocyte development results from a cascade of temporally ordered random gene shuffling translocations by a recombinase that join any one of multiple alternative discrete V, D, and J (heavy chain) or V and J (light chain) antibody gene variable region DNA coding segments that produce in each B-lymphocyte an antibody with a unique antigen binding region composed of a heavy and a light protein chain. In addition, splicing inaccuracies or insertion of additional nucleotides at the segment junctions generate further junctional diversity and somatic hypermutation of V regions, as B-lymphocytes proliferate, create better fitting antigen-binding sites.NCI
code
  • C26555
is someValuesFrom of
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