About: Laromustine     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Laromustine
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Laromustine
NSC_Code
  • 734246
UMLS_CUI
  • C2713559
CAS_Registry
  • 173424-77-6
In_Clinical_Trial_For
  • Advanced or Metastatic Solid Tumors or Lymphomas; Relapsed or Refractory Leukemia or Poor-Risk Myelodysplastic Syndromes
FDA_UNII_Code
  • 14J2G0U3NQ
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat acute myelogenous leukemia (AML). It is also being studied in the treatment of several other types of cancer. It blocks cell growth by damaging the cell's DNA and may kill cancer cells. It is a type of alkylating agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38440
PDQ_Closed_Trial_Search_ID
  • 38440
Chemical_Formula
  • C6H14ClN3O5S2
Legacy_Concept_Name
  • VNP40101M
FULL_SYN
  • CloretazineSYNCI
  • LaromustinePTNCI
  • CloretazinePTNCI-GLOSSCDR0000644319
  • laromustinePTNCI-GLOSSCDR0000644318
  • 101MCNNCI
  • 1,2-Bis(methylsulfonyl)-1-(2-chloroethyl)-2-(methylaminocarbonyl)hydrazineSNNCI
  • OnriginPTNCI-GLOSSCDR0000644320
  • OnriginBRNCI
  • VNP40101MPTNCI-GLOSSCDR0000045049
  • VNP40101MCNNCI
  • LAROMUSTINEPTFDA14J2G0U3NQ
DEFINITION
  • A sulfonyl hydrazine prodrug with antineoplastic activity. Laromustine releases the DNA chloroethylating agent 90CE after entering the blood stream; 90CE chloroethylates alkylates the O6 position of guanine, resulting in DNA crosslinking, strand breaks, chromosomal aberrations, and disruption of DNA synthesis. Intracellular metabolism of this agent also releases methyl isocyanate which inhibits O6-alkyl-guanine transferase, an enzyme involved with DNA repair.NCI
code
  • C2653
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 49 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software