About: DHA-Paclitaxel     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • DHA-Paclitaxel
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • DHA-Paclitaxel
NSC_Code
  • 28247
UMLS_CUI
  • C1134470
CAS_Registry
  • 73-67-6
In_Clinical_Trial_For
  • Metastatic Pancreatic Cancer; Metastatic Colorectal Cancer; Metastatic Hormone-Refractory Prostate Cancer; Advanced Solid Tumors or Unresectable Pancreatic Cancer.
ALT_DEFINITION
  • A combination of DHA (a natural fatty acid) and paclitaxel (an anticancer drug) being studied in the treatment of cancer. It is a type of mitotic inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38414
PDQ_Closed_Trial_Search_ID
  • 38414
Legacy_Concept_Name
  • DHA-Paclitaxel
FULL_SYN
  • DHA-PaclitaxelPTNCI
  • TXPABNCI
  • DHA-paclitaxelPTNCI-GLOSSCDR0000045043
  • Docosahexaenoic Acid-Paclitaxel conjugateSYNCI
  • TaxoprexinBRNCI
DEFINITION
  • A prodrug comprised of the naturally occurring omega-3 fatty acid docosahexaenoic acid (DHA) covalently conjugated to the anti-microtubule agent paclitaxel. Because tumor cells take up DHA, DHA-paclitaxel is delivered directly to tumor tissue, where the paclitaxel moiety binds to tubulin and inhibits the disassembly of microtubules, thereby resulting in the inhibition of cell division. Paclitaxel also induces apoptosis by binding to and blocking the function of the apoptosis inhibitor protein Bcl-2 (B-cell Leukemia 2). DHA-paclitaxel exhibits improved pharmacokinetic and toxicity profiles when compared to conventional paclitaxel and has demonstrated antineoplastic activity in animal models of cancer. (NCI04)NCI
code
  • C2649
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