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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Doxercalciferol
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Doxercalciferol
UMLS_CUI
  • C0043668
CAS_Registry
  • 54573-75-0
Accepted_Therapeutic_Use_For
  • Secondary hyperparathyroidism in end stage renal disease in patients on hemodialysis.
In_Clinical_Trial_For
  • Osteoporosis; localized prostate cancer; myelodysplastic syndrome or chronic myelomonocytic leukemia.
FDA_UNII_Code
  • 3DIZ9LF5Y9
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the prevention of recurrent prostate cancer. It is a type of vitamin D analog.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38406
PDQ_Closed_Trial_Search_ID
  • 38406
Chemical_Formula
  • C28H44O2
Legacy_Concept_Name
  • Doxercalciferol
FULL_SYN
  • (1alpha,3beta,5Z,7E,22E)-9,10-Secoergosta-5,7,10(19),22-tetraene-1,3-diolSNNCI
  • 1-Alpha-Hydroxyvitamin D2SNNCI
  • DOXERCALCIFEROLPTFDA3DIZ9LF5Y9
  • DoxercalciferolPTNCI
  • HectorolBRNCI
  • doxercalciferolPTNCI-GLOSSCDR0000045041
  • DoxercalciferolPTDCP20079
DEFINITION
  • A synthetic analog of vitamin D with potential antineoplastic activity. In the liver, doxercalciferol is converted to its biologically active vitamin D metabolites, which control the intestinal absorption of dietary calcium, the tubular reabsorption of calcium by the kidney and, in conjunction with parathyroid hormone (PTH), the mobilization of calcium from the skeleton. Through interaction with specific receptor proteins in target tissues, these vitamin D metabolites act directly on osteoblasts to stimulate skeletal growth, and on the parathyroid glands to suppress PTH synthesis and secretion. This agent has also been shown to inhibit the growth of retinoblastomas, and may exhibit some antiproliferative activity against prostate cancer cells.NCI
code
  • C2645
sameAs
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