About: Immunoglobulin Kappa Locus     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Immunoglobulin Kappa Locus
equivalentClass
GenBank_Accession_Number
  • NG_000833
Semantic_Type
  • Gene or Genome
Preferred_Name
  • Immunoglobulin Kappa Locus
UMLS_CUI
  • C1366332
EntrezGene_ID
  • 50802
Legacy_Concept_Name
  • Immunoglobulin_Kappa_Locus
HGNC_ID
  • HGNC:5715
FULL_SYN
  • Kappa Light Chain GeneSYNCI
  • Immunoglobulin Kappa LocusSYNCITCGA
  • Immunoglobulin Kappa GeneSYNCI
  • IGKSYNCI
  • Immunoglobulin Kappa LocusPTNCI
  • IGK@SYNCI
Gene_Encodes_Product
  • Immunoglobulin Light Chain, Kappa
DEFINITION
  • This region represents the germline organization of the kappa light chain locus. The locus includes V (variable), J (joining), and C (constant) segments. During B cell development, a recombination event at the DNA level joins a single V segment with a J segment; the C segment is later joined by splicing at the RNA level. Recombination of many different V segments with several J segments provides a wide range of antigen recognition. Additional diversity is attained by junctional diversity, resulting from the random additional of nucleotides by terminal deoxynucleotidyltransferase, and by somatic hypermutation, which occurs during B cell maturation in the spleen and lymph nodes. (from LocusLink)NCI
code
  • C26425
is someValuesFrom of
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