About: Idronoxil     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Idronoxil
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Idronoxil
UMLS_CUI
  • C1134444
CAS_Registry
  • 81267-65-4
In_Clinical_Trial_For
  • Refractory Solid Tumors
FDA_UNII_Code
  • 995FT1W541
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It belongs to the family of drugs called signal transduction inhibitors.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 38371
PDQ_Closed_Trial_Search_ID
  • 38371
Chemical_Formula
  • C15H12O3
Legacy_Concept_Name
  • Phenoxodiol
FULL_SYN
  • IdronoxilPTNCI
  • PhenoxodiolSYNCI
  • 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-olPTDCP32001
  • phenoxodiolPTNCI-GLOSSCDR0000045038
  • NV-06CNNCI
  • IDRONOXILPTFDA995FT1W541
  • 3-(4-Hydroxyphenyl)-2H-1-benzopyran-7-olSNNCI
DEFINITION
  • A synthetic flavonoid derivative. Idronoxil activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), and disrupts FLICE inhibitory protein (FLIP) expression, resulting in tumor cell apoptosis. This agent also inhibits DNA topoisomerase II by stabilizing the cleavable complex, thereby preventing DNA replication and resulting in tumor cell death.NCI
code
  • C2642
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