About: Serine/Threonine-Protein Kinase LATS1     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Serine/Threonine-Protein Kinase LATS1
equivalentClass
OMIM_Number
  • 603473
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Serine/Threonine-Protein Kinase LATS1
UMLS_CUI
  • C1259016
Legacy_Concept_Name
  • Large_Tumor_Suppressor_Homolog-1_Protein
FULL_SYN
  • EC 2.7.11.1SYNCI
  • LATS1 ProteinSYNCI
  • Large Tumor Suppressor 1SYNCI
  • LATS Homolog 1SYNCI
  • Serine/Threonine-Protein Kinase LATS1PTNCI
  • LATS1SYNCI
  • LATS (Large Tumor Suppressor) Homolog 1SYNCI
  • h-wartsSYNCI
  • WARTS Protein KinaseSYNCI
  • Large Tumor Suppressor Homolog 1SYNCI
Swiss_Prot
  • O95835
DEFINITION
  • Serine/threonine-protein kinase LATS1 (1130 aa, ~127 kDa) is encoded by the human LATS1 gene. This protein plays a role in both mitosis and serine/threonine phosphorylation.NCI
DesignNote
  • LATS1 is a negative regulator of CDC2/cyclin A. In early mitosis, it complexes (via the N-terminal region) with the mitotic apparatus cell cycle controller CDC2 kinase; the complex shows reduced H1 histone kinase activity.
code
  • C26344
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