About: Tucotuzumab Celmoleukin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tucotuzumab Celmoleukin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Tucotuzumab Celmoleukin
UMLS_CUI
  • C1721369
CAS_Registry
  • 339986-90-2
In_Clinical_Trial_For
  • Renal Cell Carcinoma and Refractory Epithelial Carcinoma.
FDA_UNII_Code
  • 4ON7FF680U
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 456358
PDQ_Closed_Trial_Search_ID
  • 456358
Legacy_Concept_Name
  • KSA-Interleukin-2_Fusion_Protein
FULL_SYN
  • huKS-IL2 Fusion ProteinSYNCI
  • Tucotuzumab CelmoleukinPTNCI
  • TUCOTUZUMAB CELMOLEUKINPTFDA4ON7FF680U
  • KSA-interleukin-2SYNCI
  • KSA-IL-2ABNCI
  • EMD 273066CNNCI
  • EMD-273066CNNCI
  • KSA-Interleukin-2 Fusion ProteinSYNCI
DEFINITION
  • A recombinant fusion protein comprised of a human monoclonal antibody directed against the epithelial cell adhesion molecule (EpCAM or KS) linked to an active interleukin-2 (IL2) molecule with potential antineoplastic activity. Tucotuzumab Celmoleukin recognizes and binds to EpCAM, a cell surface epithelial protein that is expressed on a wide variety of cancer cells, thereby concentrating IL2 in EpCAM-expressing tumor tissue. Subsequently, the localized IL2 moiety of the fusion protein may stimulate a cytotoxic T-cell antitumor immune response.NCI
code
  • C2630
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