About: Immunoglobulin Class Switch Recombination     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Immunoglobulin Class Switch Recombination
rdfs:subClassOf
Semantic_Type
  • Genetic Function
Preferred_Name
  • Immunoglobulin Class Switch Recombination
UMLS_CUI
  • C1512667
Legacy_Concept_Name
  • Immunoglobulin_Switch_Recombination
FULL_SYN
  • Immunoglobulin Isotype-Switch RecombinationSYNCI
  • Immunoglobulin Switch RecombinationSYNCI
  • Switch RecombinationSYNCI
  • Immunoglobulin Class Switch RecombinationPTNCI
DEFINITION
  • Any process of gene rearrangement in which one immunoglobulin heavy chain constant coding region is exchanged for another, with the loss of the intervening region, resulting in an altered profile of effector molecule interactions for the antibody produced. During this process the variable coding region of the heavy chain remains unchanged, thus retaining antigen specificity. Immunoglobulin class switch recombination is involved in the maturation of an immune respone toward a particular antigen.NCI
code
  • C26279
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