About: Carmustine in Ethanol     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Carmustine in Ethanol
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Clinical Drug
Preferred_Name
  • Carmustine in Ethanol
UMLS_CUI
  • C0935694
In_Clinical_Trial_For
  • Recurrent supratentorial malignant glioma or metastatic neoplasm to the brain.
PDQ_Open_Trial_Search_ID
  • 38104
PDQ_Closed_Trial_Search_ID
  • 38104
Legacy_Concept_Name
  • Carmustine_in_Ethanol
FULL_SYN
  • DTI-015CNNCI
  • Carmustine in EthanolPTNCI
DEFINITION
  • A formulation containing carmustine dissolved in ethanol for intra-tumoral administration that allows carmustine to enter both aqueous and lipid compartments of the target tissue. As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Carmustine also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily.NCI
code
  • C2602
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