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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Psoralen
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Psoralen
NSC_Code
  • 217989
UMLS_CUI
  • C0016072
CAS_Registry
  • 66-97-7
Accepted_Therapeutic_Use_For
  • Psoriasis; T-cell Lymphoma-Cutaneous; Vitiligo
FDA_UNII_Code
  • KTZ7ZCN2EX
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance from plants that is sensitive to light (or can be activated by light). Psoralens are used together with UV light to treat psoriasis, vitiligo, and skin nodules of cutaneous T-cell lymphoma. They are also being studied in the treatment of graft-versus-host disease. Psoralen is a type of furocoumarin. An example of a psoralen is methoxsalen.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37899
PDQ_Closed_Trial_Search_ID
  • 37899
Chemical_Formula
  • C11H6O3
Legacy_Concept_Name
  • Psoralen
CHEBI_ID
  • CHEBI:27616
FULL_SYN
  • 6-hydroxy-5-benzofuranacrylic Acid deta-lactonSNNCI
  • PSORALENPTFDAKTZ7ZCN2EX
  • PSORALENSYDTPNSC0217989
  • PsoralenSYDTPNSC0404562
  • FicusinSYNCI
  • psoralenPTNCI-GLOSSCDR0000044900
  • PsoralenPTNCI
DEFINITION
  • A furocoumarin that intercalates with DNA, inhibiting DNA synthesis and cell division. Psoralen is used in Photochemotherapy with high-intensity long-wavelength UVA irradiation. Psoralens are tricyclic furocumarins and have a strong tendency to intercalate with DNA base pairs. Irradiation of nucleic acids in the presence of psoralen with long wave UV (~360 nm) results in the 2+2 cyclo- addition of either of its two photoreactive sites with 5,6-carbon bonds of pyrimidines resulting in crosslinking double-stranded nucleic acids.NCI
code
  • C2586
sameAs
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