About: T-cell Receptor Excision Circle     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • T-cell Receptor Excision Circle
rdfs:subClassOf
Semantic_Type
  • Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name
  • T-cell Receptor Excision Circle
UMLS_CUI
  • C2964522
Legacy_Concept_Name
  • T-Cell_Receptor-Rearrangement_Excision_DNA_Circles
FULL_SYN
  • TRECABNCI
  • T-Cell Receptor-Rearrangement Excision DNA CircleSYNCI
  • T-cell Receptor Excision CirclePTNCI
DEFINITION
  • The reciprocal product of T-cell receptor (TCR) gene rearrangement. Following TCR gene rearrangement the T-cell receptor excision circle (TREC) is maintained in the cell as a non-replicating episome. With each cell division the TREC is segregated to a single daughter cell and becomes diluted in the population. Recent TCR rearrangement can be detected by a spike in the number of TREC and can be used to quantify thymic T-cell output.NCI
code
  • C2561
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