About: MG 98

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Attributes	Values
rdf:type	Class
rdfs:label	MG 98
rdfs:subClassOf	DNA Methyltransferase Inhibitors Mixed-Backbone Oligonucleotide
Semantic_Type	Pharmacologic Substance Nucleic Acid, Nucleoside, or Nucleotide
Preferred_Name	MG 98
UMLS_CUI	C0796640
ALT_DEFINITION	A substance being studied in the treatment of cancer. It blocks the production of a protein called DNA methyltransferase, which helps control gene expression. This may kill cancer cells that need DNA methyltransferase to grow. It is a type of antisense oligonucleotide.NCI-GLOSS
PDQ_Open_Trial_Search_ID	43475
PDQ_Closed_Trial_Search_ID	43475
Legacy_Concept_Name	MG_98
FULL_SYN	MG98PTNCI-GLOSSCDR0000046689 MG 98CNNCI MG 98PTNCI MG-98CNNCI MG-98 oligonucleotideSYNCI
DEFINITION	A second-generation, mixed-backbone, phosphorothioate antisense oligonucleotide (ODN) with potential antitumor activity. MG 98 is a highly specific inhibitor of translation of the mRNA for human DNA (cytosine-5-)-methyltransferase 1 (DNMT1), hybridizing to the 3' un-translated region of DNMT1 mRNA. The silencing of DNMT1 translation by MG 98 may result in the prevention or reversal of abnormal methylation of tumor suppressor genes and ultimately in tumor growth inhibition or tumor regression.NCI
code	C2530

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