About: Iodine I 131 Monoclonal Antibody BC8     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Iodine I 131 Monoclonal Antibody BC8
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Iodine I 131 Monoclonal Antibody BC8
UMLS_CUI
  • C0796627
In_Clinical_Trial_For
  • Advanced Myeloid Leukemia; Acute Myelogenous Leukemia in First Remission; Advanced Acute Lymphocytic Leukemia; Advanced Acute Myeloid Leukemia or Myelodysplastic Syndrome.
ALT_DEFINITION
  • A monoclonal antibody that contains the radioactive substance iodine I131. It is being studied in the treatment of acute myeloid leukemia. Monoclonal antibodies are made in the laboratory and can locate and bind to cancer cells. Iodine I 131 monoclonal antibody BC8 binds to the protein CD45, which is found on most white blood cells and myeloid and lymphoid leukemia cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43463
PDQ_Closed_Trial_Search_ID
  • 43463
Legacy_Concept_Name
  • I_131_Monoclonal_Antibody_BC8
FULL_SYN
  • I 131 MOAB BC8ABNCI
  • Iodine I 131 Monoclonal Antibody BC8PTNCI
  • monoclonal antibody BC8, iodine I 131SYNCI
  • I 131 Monoclonal Antibody BC8SYNCI
  • iodine I 131 monoclonal antibody BC8PTNCI-GLOSSCDR0000443020
  • iodine I 131 MOAB BC8SYNCI
  • MOAB BC8, iodine I 131SYNCI
DEFINITION
  • A radioimmunoconjugate consisting of BC8, a murine IgG1 anti-CD45 monoclonal antibody labeled with iodine 131 (I-131), with radioimmunotherapeutic properties. Using monoclonal antibody BC8 as a carrier for I-131 results in the targeted destruction of cells expressing CD45. CD45 is tyrosine phosphatase expressed on virtually all leukocytes, including myeloid and lymphoid precursors in bone marrow and mature lymphocytes in lymph nodes; it is also expressed on most myeloid and lymphoid leukemic cells, but not on mature erythrocytes or platelets. (NCI04)NCI
code
  • C2527
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 123 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software