About: LMB-2 Immunotoxin     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • LMB-2 Immunotoxin
equivalentClass
Has_Target
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • LMB-2 Immunotoxin
NSC_Code
  • 676422
UMLS_CUI
  • C0655013
In_Clinical_Trial_For
  • CD-25 positive leukemia and lymphoma
ALT_DEFINITION
  • A toxic substance linked to an antibody that attaches to tumor cells and kills them.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43377
PDQ_Closed_Trial_Search_ID
  • 43377
Legacy_Concept_Name
  • LMB-2_Immunotoxin
FULL_SYN
  • LMB-2 immunotoxinPTNCI-GLOSSCDR0000046198
  • Humanized AntiTac ToxinSYNCI
  • LMB-2 (Anti-TAC(FV)-PE-38)SYNCI
  • LMB-2ABNCI
  • Anti-Tac(Fv)-PE38SYNCI
  • LMB-2 ImmunotoxinPTNCI
  • Immunotoxin LMB-2SYNCI
DEFINITION
  • A fusion protein consisting of the Fv portion of a monoclonal antibody attached to a 38-kDa fragment of the Pseudomonas exotoxin A (with amino acids 365-380 deleted). LMB-2 immunotoxin targets the interleukin 2 receptor (also known as IL-2R or CD25) which is expressed on activated normal T and B cells and macrophages and on the cells of various hematologic malignancies. The antibody attaches to the IL-2R on the cell membrane, facilitating the entry of the exotoxin. The exotoxin moiety induces caspase-mediated apoptosis of tumor cells via a mechanism involving mitochondrial damage; it also catalyzes the transfer of ADP ribose from nicotinamide adenine dinucleotide (NAD) to elongation factor-2 in eukaryotic cells, thereby inactivating elongation factor 2 and inhibiting protein synthesis. (NCI04)NCI
code
  • C2513
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