About: Hu14.18-IL2 Fusion Protein     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Hu14.18-IL2 Fusion Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Hu14.18-IL2 Fusion Protein
NSC_Code
  • 721298
UMLS_CUI
  • C1529682
In_Clinical_Trial_For
  • Neuroblastoma
ALT_DEFINITION
  • An anticancer drug in which hu14.18, a monoclonal antibody, is combined with interleukin-2. The monoclonal antibody binds to the cancer cells and delivers IL-2, which stimulates the immune system to destroy the cancer cells.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43349
PDQ_Closed_Trial_Search_ID
  • 43349
Legacy_Concept_Name
  • Hu14_18-Interleukin-2_Fusion_Protein
FULL_SYN
  • Hu14.18-IL2ABNCI
  • Hu14.18-IL2 Fusion ProteinPTNCI
  • Hu 14.18/IL - 2 Fusion ProteinSYNCI
  • hu14.18-interleukin-2 fusion proteinPTNCI-GLOSSCDR0000046190
  • EMD 273063CNNCI
DEFINITION
  • A recombinant protein consisting of the hu14.18 monoclonal antibody fused to the cytokine interleukin-2 (IL2) with potential antineoplastic activity. The monoclonal antibody portion of the hu14.18-IL2 fusion protein binds to tumor cells expressing the GD2 antigen (melanoma, neuroblastoma and certain other tumors); the Fc component of the fusion protein antibody moiety and natural killer (NK) cells mediate antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cellular cytotoxicity (CDCC) towards GD2-expressing tumor cells. The localized IL2 moiety of the fusion protein stimulates NK and T-cell antitumor cellular immune responses.NCI
code
  • C2509
http://linked.open...y/mesh/hasConcept
Faceted Search & Find service v1.16.118 as of Jun 21 2024


Alternative Linked Data Documents: ODE     Content Formats:   [cxml] [csv]     RDF   [text] [turtle] [ld+json] [rdf+json] [rdf+xml]     ODATA   [atom+xml] [odata+json]     Microdata   [microdata+json] [html]    About   
This material is Open Knowledge   W3C Semantic Web Technology [RDF Data] Valid XHTML + RDFa
OpenLink Virtuoso version 07.20.3240 as of Jun 21 2024, on Linux (x86_64-pc-linux-gnu), Single-Server Edition (126 GB total memory, 121 GB memory in use)
Data on this page belongs to its respective rights holders.
Virtuoso Faceted Browser Copyright © 2009-2024 OpenLink Software