About: Cisplatin Liposomal     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Cisplatin Liposomal
rdfs:subClassOf
Semantic_Type
  • Inorganic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Cisplatin Liposomal
NSC_Code
  • 719334
UMLS_CUI
  • C0964924
In_Clinical_Trial_For
  • Recurrent platinum sensitive ovarian epithelial cancer.
PDQ_Open_Trial_Search_ID
  • 43292
PDQ_Closed_Trial_Search_ID
  • 43292
Legacy_Concept_Name
  • Cisplatin_Liposomal
FULL_SYN
  • STEALTH Liposome CisplatinSYNCI
  • STEALTH Liposomal CisplatinSYNCI
  • STEALTH CisplatinSYNCI
  • SPI-77CNNCI
  • SPI-077CNNCI
  • STEALTH Liposomal Encapsulated CisplatinSYNCI
  • Cisplatin LiposomalPTNCI
  • Liposomal CisplatinSYNCI
  • Cisplatin, LiposomalSYNCI
DEFINITION
  • A synthetic formulation in which the antineoplastic agent cisplatin is encapsulated in lipids. Cisplatin liposomal consists of small aggregates of cisplatin covered by a single lipid bilayer. Encasement in liposomes improves cisplatin's tumor bioavailability and toxicity profile. Liposomal encapsulation does not affect the pharmacological properties of cisplatin directly. Cisplatin forms highly reactive, charged, platinum complexes which bind to nucleophilic groups such as GC-rich sites in DNA, inducing intrastrand and interstrand DNA cross-links, as well as DNA-protein cross-links. These cross-links result in apoptosis and cell growth inhibition. (NCI04)NCI
code
  • C2502
http://linked.open...y/mesh/hasConcept
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