About: Polifeprosan 20 with Carmustine Implant     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Polifeprosan 20 with Carmustine Implant
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Polifeprosan 20 with Carmustine Implant
NSC_Code
  • 714372
UMLS_CUI
  • C0796325
Accepted_Therapeutic_Use_For
  • Malignant glioma, adjuvant to surgery and radiation; Recurrent glioblastoma multiforme, adjuvant to surgery
ALT_DEFINITION
  • A biodegradable wafer that is used to deliver the anticancer drug carmustine directly into a brain tumor site after the tumor has been removed by surgery.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 43142
PDQ_Closed_Trial_Search_ID
  • 43142
Legacy_Concept_Name
  • Polifeprosan_20_with_Carmustine_Implant
FULL_SYN
  • Gliadel WaferBRNCI
  • Gliadel WaferPTNCI-GLOSSCDR0000306512
  • polifeprosan 20 carmustine implantPTNCI-GLOSSCDR0000306511
  • Polifeprosan 20 with Carmustine ImplantPTNCI
  • Carmustine CopolymerSYNCI
DEFINITION
  • A synthetic, biodegradable wafer containing the agent carmustine with antineoplastic activity. Used to deliver drug directly into a brain tumor site and typically implanted post-surgically, the wafer is made of a biodegradable poly-anhydride copolymer and contains the nitrosourea carmustine. As an antineoplastic nitrosourea, carmustine alkylates and cross-links DNA during all phases of the cell cycle, resulting in disruption of DNA function, cell cycle arrest, and apoptosis. Carmustine also carbamoylates proteins, including DNA repair enzymes, resulting in an enhanced cytotoxic effect. Carmustine is highly lipophilic and crosses the blood-brain barrier readily. (NCI04)NCI
code
  • C2487
is someValuesFrom of
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