About: Arzoxifene Hydrochloride     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Arzoxifene Hydrochloride
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Arzoxifene Hydrochloride
UMLS_CUI
  • C0950979
CAS_Registry
  • 182133-27-3
FDA_UNII_Code
  • FU88PI0433
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of osteoporosis and breast cancer. Arzoxifene hydrochloride is made in the laboratory and binds to estrogen receptors in the body. It is a type of selective estrogen receptor modulator (SERM).NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42856
PDQ_Closed_Trial_Search_ID
  • 42856
Chemical_Formula
  • C28H29NO4S.HCl
Legacy_Concept_Name
  • Arzoxifene_Hydrochloride
FULL_SYN
  • 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol hydrochlorideSNNCI
  • LY353381.HCLCNNCI
  • LY353381.HClCNNCI
  • arzoxifene hydrochlorideSYNCI-GLOSSCDR0000579913
  • ArzoxifenehydrochlorideSYNCI
  • Arzoxifene HydrochloridePTNCI
  • SERM3SYNCI
  • ARZOXIFENE HYDROCHLORIDEPTFDAFU88PI0433
  • SERM-3CNNCI
  • SERM-3SYNCI
  • LY353381 hydrochloridePTNCI-GLOSSCDR0000045759
  • Arzoxifene.HClPTDCP20000
  • LY353381 HydrochlorideSYNCI
DEFINITION
  • The hydrochloride salt of arzoxifene, a synthetic aromatic derivative with anti-estrogenic properties. Arzoxifene binds to estrogen receptors as a mixed estrogen agonist/antagonist. In comparison to other selective estrogen receptor modulators (SERMs), arzoxifene exhibits greater bioavailability and higher anti-estrogenic potency in the breast than raloxifene; it exhibits reduced estrogenicity in the uterus compared with either tamoxifen or raloxifene. This agent may have beneficial effects on bone and the cardiovascular system.NCI
code
  • C2460
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