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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Incyclinide
equivalentClass
Has_Target
Concept_In_Subset
Semantic_Type
  • Antibiotic
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Incyclinide
NSC_Code
  • 683551
UMLS_CUI
  • C0763138
CAS_Registry
  • 15866-90-7
In_Clinical_Trial_For
  • HIV-related Kaposi sarcoma; progressive or recurrent brain tumor; advanced solid tumor
FDA_UNII_Code
  • 21G64WZQ4I
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance being studied in the treatment of cancer. COL-3 may block the growth of new blood vessels that tumors need to grow. It is a type of matrix metalloproteinase inhibitor and a type of antiangiogenesis agent.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 42884
PDQ_Closed_Trial_Search_ID
  • 42884
Chemical_Formula
  • C19H17NO7
Legacy_Concept_Name
  • COL-3
FULL_SYN
  • 6-deoxy, 6-demethyl, 4-de-dimethylamino tetracyclineSNNCI
  • IncyclinidePTNCI
  • COL-3PTNCI-GLOSSCDR0000045574
  • 4-DimethlyaminosancyclineSNNCI
  • 4-Dimethlyamino SancyclineSNNCI
  • COL 3CNNCI
  • COL-3CNNCI
  • CMT-3CNNCI
  • 4-dedimethylamino sancyclineSNNCI
  • 6-deoxy-6-demethyl-4-dedimethylaminotetracyclineSNNCI
  • Tetracycline CMT-3SYNCI
  • MetastatBRNCI
  • INCYCLINIDEPTFDA21G64WZQ4I
  • MetastatPTDCP31767
DEFINITION
  • A chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.NCI
code
  • C2454
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