About: Monoclonal Antibody 11D10     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Monoclonal Antibody 11D10
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Immunologic Factor
Preferred_Name
  • Monoclonal Antibody 11D10
PubMedID_Primary_Reference
  • 7533665
UMLS_CUI
  • C0677765
PDQ_Open_Trial_Search_ID
  • 42822
PDQ_Closed_Trial_Search_ID
  • 42822
Legacy_Concept_Name
  • Monoclonal_Antibody_11D10
FULL_SYN
  • Monoclonal Antibody 11D10PTNCI
  • 11D10SYNCI
  • MoAb 11D10ABNCI
DEFINITION
  • A murine monoclonal anti-idiotype antibody (anti-Id). Anti-Id 11D10 mimics a specific epitope of the high molecular weight human milk fat globule (HMFG) glycoprotein primarily expressed by human breast and some other tumor cells at high density. This specific HMFG epitope is identified by mAb BrE1, which was used as the immunizing antibody, or Ab1 to generate the anti-Id (Ab2) 11D10. Anti-ID 11D10 reacts specifically with breast tumor cells and with minimal reactivity with normal tissues. Vaccination with anti-Id 11D10 induces anti-anti-idiotype antibodies (Ab3) that may react with breast cancer cell lines expressing the HMFG membrane epitope.NCI
code
  • C2446
is rdfs:subClassOf of
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