About: Iodine I 131 Tositumomab

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Iodine I 131 Tositumomab
rdfs:subClassOf	Radioimmunoconjugate
Has_Target	Antigens, CD20
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Pharmacologic Substance Immunologic Factor
Preferred_Name	Iodine I 131 Tositumomab
NSC_Code	715813
UMLS_CUI	C0768182
CAS_Registry	192391-48-3
Accepted_Therapeutic_Use_For	CD-20-antigen-expressing, relapsed or refractory, low-grade, follicular, or transformed Non-Hodgkins lymphoma
In_Clinical_Trial_For	Mantle cell lymphoma; Non-Hodgkins lymphoma
FDA_UNII_Code	K1KT5M40JC
Contributing_Source	FDA
ALT_DEFINITION	A monoclonal antibody (tositumomab) that has been chemically changed by adding radioactive iodine, and that is used in the treatment of certain types of non-Hodgkin lymphoma. It belongs to the family of drugs called radioconjugated monoclonal antibodies. When iodine I 131 tositumomab and tositumomab are given together, the combination is called the Bexxar regimen.NCI-GLOSS
PDQ_Open_Trial_Search_ID	42806
PDQ_Closed_Trial_Search_ID	42806
Legacy_Concept_Name	I_131_Monoclonal_Antibody_Anti-B1
FULL_SYN	131-I-Anti-B1 Monoclonal AntibodySYNCI I 131 Monoclonal Antibody Anti-B1SYNCI Iodine-131 TositumomabSYNCI I131-MOAB-B1ABNCI Iodine I 131 TositumomabPTNCI Iodine I 131 MOAB Anti-B1SYNCI Iodine-131 Anti-B1 AntibodySYNCI I 131 TositumomabSYNCI TOSITUMOMAB I-131PTFDAK1KT5M40JC Iodine-131 Anti-CD20 Monoclonal AntibodySYNCI Iodine I 131 Monoclonal Antibody Anti-B1SYNCI iodine I 131 tositumomabPTNCI-GLOSSCDR0000367409
DEFINITION	A monoclonal antibody directed against the CD20 protein expressed on the surface of B-lymphocytes and radiolabeled with the radioisotope iodine I 131 with potential antineoplastic activity. Iodine I 131 tositumomab binds to and selectively delivers cyctotoxic radiation to CD20-expressing B-lymphocytes, thereby minimizing systemic radiotoxicity.NCI
code	C2444
sameAs	TOSITUMOMAB IODINE-131 TOSITUMOMAB IODINE-131
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0305901
is someValuesFrom of	nodeID://b663024 nodeID://b663280 nodeID://b663336 nodeID://b720093
is sameAs of	TOSITUMOMAB IODINE-131 TOSITUMOMAB IODINE-131 TOSITUMOMAB IODINE-131

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