About: Sargramostim Plasmid DNA Sarcoma Vaccine     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Sargramostim Plasmid DNA Sarcoma Vaccine
rdfs:subClassOf
Semantic_Type
  • Pharmacologic Substance
  • Immunologic Factor
Preferred_Name
  • Sargramostim Plasmid DNA Sarcoma Vaccine
UMLS_CUI
  • C0393070
In_Clinical_Trial_For
  • Sarcoma
PDQ_Open_Trial_Search_ID
  • 42678
PDQ_Closed_Trial_Search_ID
  • 42678
Legacy_Concept_Name
  • Sargramostim_Plasmid_DNA_Sarcoma_Vaccine
FULL_SYN
  • GM-CSF plasmid DNA sarcoma vaccineSYNCI
  • Sargramostim Plasmid DNA Sarcoma VaccinePTNCI
DEFINITION
  • An autologous sarcoma cell vaccine with potential immunostimulatory activity. Tumor cells harvested from a patient with sarcoma are transfected with a plasmid DNA encoding for human sargramostim (GM-CSF) using a particle-mediated gene transfer (PMGT) technique, which avoids the use of infectious components. Vaccination with an autologous sargramostim sarcoma vaccine produces high levels of GM-CSF, a cytokine that enhances antigen presentation by activated macrophages and increases the recognition of weakly immunogenic tumors by cytotoxic T-lymphocytes.NCI
code
  • C2429
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