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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Diethylhomospermine
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Diethylhomospermine
UMLS_CUI
  • C0067118
In_Clinical_Trial_For
  • Refractory Malignancies and Refractory AIDS-Related Diarrhea.
PDQ_Open_Trial_Search_ID
  • 42542
PDQ_Closed_Trial_Search_ID
  • 42542
Legacy_Concept_Name
  • Diethylhomospermine
FULL_SYN
  • N(1),N(14)-bis(ethyl)homospermineSNNCI
  • N1N14-diethylhomospermineSNNCI
  • N1,N14-diethylhomospermineSNNCI
  • N1N14-bis(ethyl)norspermineSNNCI
  • DEHOPABNCI
  • DEHSPMABNCI
  • DiethylhomosperminePTNCI
  • 1,14-bis(ethylamino)-5,10-diazatetradecaneSNNCI
DEFINITION
  • A polyamine analogue with antiproliferative and potential anti-diarrheal activities. Diethylhomospermine (DEHSPM) antagonizes polyamine activity via NMDA receptor glutamine binding site, thereby modulating inotropic stasis and reducing stool volume (anti-diarrhea). However, due to the toxic effects from metabolites of DEHSP, other tetramine derivatives with less toxicity have been developed.NCI
code
  • C2412
http://linked.open...y/mesh/hasConcept
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