About: Tretinoin Liposome     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Tretinoin Liposome
rdfs:subClassOf
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tretinoin Liposome
UMLS_CUI
  • C0338222
In_Clinical_Trial_For
  • Metastatic renal cell carcinoma
  • Metastatic Renal Cell Carcinoma; Relapsed Acute Promyelocytic Leukemia; Recurrent or Refractory Hodgkins Disease; Karposi Sarcoma.
PDQ_Open_Trial_Search_ID
  • 42285
PDQ_Closed_Trial_Search_ID
  • 42285
Legacy_Concept_Name
  • Tretinoin_Liposome
FULL_SYN
  • TretinoinLFSYNCI
  • All-trans-retinoic acid liposomalSYNCI
  • Liposomal all-trans-retinoic acidSYNCI
  • AR-623CNNCI
  • Tretinoin LiposomePTNCI
  • AtragenBRNCI
  • Tretinoin LiposomalSYNCI
  • Liposomal tretinoinSYNCI
DEFINITION
  • An intravenous formulation of tretinoin (vitamin A acid or all-trans retinoic acid) encased in liposomes. Tretinoin is a naturally occurring retinoic acid agent that binds to and activates retinoic acid receptors (RAR), effecting changes in gene expression that lead to cell differentiation, decreased cell proliferation, and inhibition of carcinogenesis. This agent also inhibits telomerase, leading to telomere shortening and eventual apoptosis of certain tumor cell types. Liposome encapsulation extends the half-life of intravenously administered tretinoin.NCI
code
  • C2398
is someValuesFrom of
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