About: DAB389 Epidermal Growth Factor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • DAB389 Epidermal Growth Factor
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • DAB389 Epidermal Growth Factor
UMLS_CUI
  • C0281573
PDQ_Open_Trial_Search_ID
  • 42032
PDQ_Closed_Trial_Search_ID
  • 42032
Legacy_Concept_Name
  • DAB389_Epidermal_Growth_Factor
FULL_SYN
  • DAB389 Epidermal Growth FactorPTNCI
  • DAB389 EGFABNCI
DEFINITION
  • A recombinant fusion protein composed of the diphtheria toxin with the receptor-binding domain replaced by human epidermal growth factor (EGF). When administered, EGF binds to the endothelial cell growth factor receptor, EGFR, which is upregulated in many solid tumors. After binding to the EGF receptor, the agent is internalized by the cell, where the diphtheria toxin moiety exerts its cytotoxic effect, inhibiting protein synthesis through ADP-ribosylation of elongation factor 2. (NCI04)NCI
code
  • C2383
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