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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Etanercept
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Etanercept
UMLS_CUI
  • C0717758
CAS_Registry
  • 185243-69-0
Accepted_Therapeutic_Use_For
  • juvenile arthritis; psoriatic arthritis; rheumatoid arthritis.
In_Clinical_Trial_For
  • bone marrow transplant and adjuvant use for caner-related anorexia; cachexia; stomatitis
FDA_UNII_Code
  • OP401G7OJC
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug that is commonly used to treat arthritis. It is also being studied in the treatment of cancer, and as a treatment for loss of appetite and weight loss in cancer patients. It belongs to the family of drugs called tumor necrosis factor (TNF) antagonists.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 257809
PDQ_Closed_Trial_Search_ID
  • 257809
Legacy_Concept_Name
  • Etanercept
FULL_SYN
  • etanerceptPTNCI-GLOSSCDR0000285635
  • EnbrelBRNCI
  • TNFR:FcABNCI
  • ETANERCEPTPTFDAOP401G7OJC
  • Tumor Necrosis Factor Receptor IgG ChimeraSYNCI
  • EtanerceptPTNCI
DEFINITION
  • A recombinant soluble dimeric fusion protein consisting of the extracellular ligand-binding region of recombinant human tumor necrosis factor (rhTNF) receptor attached to the constant (Fc) region of human immunoglobulin G (FcIgG). The receptor moiety of etanercept binds to circulating TNF (2 molecules of TNF per receptor) and inhibits its attachment to endogenous TNF cell surface receptors, thereby rendering TNF inactive and inhibiting TNF-mediated mechanisms of inflammation. (NCI04)NCI
code
  • C2381
sameAs
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