About: Recombinant Soluble Human CD4 Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Recombinant Soluble Human CD4 Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Pharmacologic Substance
Preferred_Name
  • Recombinant Soluble Human CD4 Protein
UMLS_CUI
  • C0279074
In_Clinical_Trial_For
  • AIDs and AIDs Related Complex.
PDQ_Open_Trial_Search_ID
  • 39062
PDQ_Closed_Trial_Search_ID
  • 39062
Legacy_Concept_Name
  • Recombinant_Soluble_Human_CD4_Protein
FULL_SYN
  • rCD4ABNCI
  • Recombinant Soluble Human CD4 ProteinPTNCI
DEFINITION
  • A recombinant human soluble CD4 with antiviral activity. Recombinant human soluble CD4 has the amino terminus but not the T-cell binding domain of the endogenous CD4 antigen. This soluble CD4 protein competitively binds to envelope glycoprotein (gp120) of human immunodeficiency virus (HIV) resulting in inhibition of interaction between gp120 and the endogenous CD4 antigen, thereby blocking viral recognition of CD4 and subsequent entry of HIV into CD4 bearing cells.NCI
code
  • C2342
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