About: Di-dgA-RFB4 Immunotoxin

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Attributes	Values
rdf:type	Class
rdfs:label	Di-dgA-RFB4 Immunotoxin
rdfs:subClassOf	CD22 Immunotoxin Ricin Immunoconjugate
Semantic_Type	Amino Acid, Peptide, or Protein Pharmacologic Substance
Preferred_Name	Di-dgA-RFB4 Immunotoxin
UMLS_CUI	C0677768
ALT_DEFINITION	An anticancer drug that is a combination of a monoclonal antibody (RFB4) and an immunotoxin (dgA).NCI-GLOSS
PDQ_Open_Trial_Search_ID	42825
PDQ_Closed_Trial_Search_ID	42825
Legacy_Concept_Name	Di-dgA-RFB4_Immunotoxin
FULL_SYN	di-dgA-RFB4PTNCI-GLOSSCDR0000046736 Di-dgA-RFB4 ImmunotoxinPTNCI Di-dgA-RFB4 Monoclonal AntibodySYNCI Monoclonal Antibody Di-dgA-RFB4SYNCI
DEFINITION	An immunotoxin of monoclonal antibody (MoAb) RFB4 covalently linked to two deglycosylated ricin toxin A-chain (Di-dgA). This agent can be extracted from castor beans. MoAb RFB4 recognizes CD22 antigen, a B-cell adhesion protein expressed on malignant cells in about 70 percent of non-Hodgkin's lymphoma and chronic lymphocytic leukemia. Ricin toxin A-chain, a potent protein synthesis inhibitor, was deglycosylated and was used in this immunoconjugate to avoid hepatic entrapment. This Di-dgA conjugated MoAb RFB4 delivers 7 fold more cytotoxicity than the single dgA immunotoxin against CD22-positive malignant cells.NCI
code	C2334

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