About: Alprazolam     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Alprazolam
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Alprazolam
UMLS_CUI
  • C0699034
CAS_Registry
  • 28981-97-7
FDA_UNII_Code
  • YU55MQ3IZY
Contributing_Source
  • FDA
ALT_DEFINITION
  • A drug used to treat anxiety disorders and panic attacks. It is being studied in the treatment of nausea and vomiting caused by some cancer treatments. It is a type of benzodiazepine.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 39659
PDQ_Closed_Trial_Search_ID
  • 39659
Chemical_Formula
  • C17H13ClN4
Legacy_Concept_Name
  • Alprazolam
CHEBI_ID
  • CHEBI:2611
FULL_SYN
  • alprazolamPTNCI-GLOSSCDR0000476309
  • XanaxPTNCI-GLOSSCDR0000572134
  • XanaxBRNCI
  • ALPRAZOLAMPTFDAYU55MQ3IZY
  • Nu-AlprazFBNCI
  • Apo-AlpzarFBNCI
  • AlprazolamPTNCI
DEFINITION
  • A triazolobenzodiazepine agent with anxiolytic, sedative-hypnotic and anticonvulsant activities. Alprazolam binds to a specific site distinct from the inhibitory neurotransmitter gamma-aminobutyric acid (GABA) binding site on the benzodiazepine-GABA-A-chloride ionophore receptor complex located in the limbic, thalamic and hypothalamic regions of the central nervous system (CNS). This binding causes an allosteric modification of the receptor and enhances the affinity of GABA to the receptor leading to an increase in the frequency of chloride-channel opening events. This leads to an increase in chloride ion conductance, neuronal hyperpolarization, inhibition of the action potential and leads to a decrease in neuronal excitability.NCI
code
  • C227
sameAs
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