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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Tariquidar
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Tariquidar
UMLS_CUI
  • C0879444
CAS_Registry
  • 206873-63-4
In_Clinical_Trial_For
  • Non-Small Cell Lung Cancer; Advanced Cancer; Relapsed or Refractory Solid Tumors.
FDA_UNII_Code
  • J58862DTVD
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance that is being studied in the treatment of cancer. It may help tumor cells respond again to drugs they have become resistant (unable to respond) to. Tariquidar is a type of multidrug resistance inhibitor and a type of P-glycoprotein antagonist.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37877
PDQ_Closed_Trial_Search_ID
  • 37877
Chemical_Formula
  • C38H38N4O6
Legacy_Concept_Name
  • Tariquidar
FULL_SYN
  • tariquidarPTNCI-GLOSSCDR0000301627
  • XR9576PTNCI-GLOSSCDR0000044895
  • XR9576CNNCI
  • TARIQUIDARPTFDAJ58862DTVD
  • TariquidarPTNCI
DEFINITION
  • An anthranilamide derivative with multidrug resistance properties. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. (NCI04)NCI
code
  • C2246
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