About: Dofequidar Fumarate     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Dofequidar Fumarate
rdfs:subClassOf
Has_Free_Acid_Or_Base_Form
Semantic_Type
  • Organic Chemical
  • Pharmacologic Substance
Preferred_Name
  • Dofequidar Fumarate
UMLS_CUI
  • C0255738
In_Clinical_Trial_For
  • Advanced Solid Malignant Tumors.
ALT_DEFINITION
  • A substance that is being studied for its ability to make cancer cells respond better to chemotherapy drugs to which they have become resistant. It belongs to the family of drugs called quinolone antibiotics.NCI-GLOSS
PDQ_Open_Trial_Search_ID
  • 37867
PDQ_Closed_Trial_Search_ID
  • 37867
Legacy_Concept_Name
  • MS-209
FULL_SYN
  • MS 209PTNCI-GLOSSCDR0000044940
  • MS-209CNNCI
  • Dofequidar FumaratePTNCI
DEFINITION
  • A synthetic quinoline derivative with multidrug resistance (MDR) modulating properties. Dofequidar fumarate, like many other MDR reversal agents, binds competitively to the drug-binding site of the transmembrane P-glycoprotein efflux pump (P-gp). Once bound to the P-gp efflux pump, dofequidar is transported out of transformed cells by a mechanism similar to that used by cytotoxic drugs, thereby blocking the efflux of these compounds from the cell. Inhibition of the efflux pump by this agent leads to a retention of the cytotoxic drug resulting in increased intracellular drug concentrations, thereby enhancing cytotoxicity. Dofequidar has demonstrated reversal of the MDR phenotype in those cells exposed to various chemotherapeutic agents, such as vinca alkaloids and anthracyclines.NCI
code
  • C2231
http://linked.open...y/mesh/hasConcept
is someValuesFrom of
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