About: Capromab Pendetide     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Capromab Pendetide
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Indicator, Reagent, or Diagnostic Aid
Preferred_Name
  • Capromab Pendetide
UMLS_CUI
  • C0529572
CAS_Registry
  • 145464-28-4
FDA_UNII_Code
  • BDO5072GRX
Contributing_Source
  • FDA
ALT_DEFINITION
  • A substance used to detect prostate cancer. It contains a monoclonal antibody that binds to prostate cells, linked to a substance that can bind radioisotopes. Capromab pendetide is combined with indium 111 and injected into the body. A gamma camera (a special camera that detects radioactivity) is used to find prostate cancer cells in the body. Capromab pendetide is a type of immunoconjugate.NCI-GLOSS
Chemical_Formula
  • C32H48N7O14
Legacy_Concept_Name
  • Capromab_Pendetide
FULL_SYN
  • ProstascintBRNCI
  • capromab pendetidePTNCI-GLOSSCDR0000597164
  • ProstaScintPTNCI-GLOSSCDR0000597163
  • 7E11-C5.3-GYK-DTPASYNCI
  • CYT-356CNNCI
  • Capromab PendetidePTNCI
  • Oncoscint ProstateBRNCI
  • CAPROMAB PENDETIDEPTFDABDO5072GRX
DEFINITION
  • An immunoconjugate of the murine monoclonal antibody, 7E11-C5.3 (Capromab), conjugated to the linker-chelator, glycyl-tyrosyl-(N,-diethylenetriaminepentaacetic acid)-lysine hydrochloride (GYK-DTPA-HCl). Capromab, an IgG1 kappa immunoglobulin, binds specifically to a cytoplasmic epitope of prostate-specific membrane glycoprotein (PSMA) that is only expressed by prostatic epithelial cells (benign and malignant). Capromab pendetide can be used in diagnosis or detection of prostate cancer when labeled with Indium I-111, which emits gamma radiation and X-Ray photons that can be captured by gamma camera allowing imaging of PMSA expressing tissues.NCI
code
  • C2209
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