About: Acridine Carboxamide

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Acridine Carboxamide
rdfs:subClassOf	Topoisomerase-II Inhibitor DNA Intercalating Agent
Concept_In_Subset	FDA Established Names and Unique Ingredient Identifier Codes Terminology
Semantic_Type	Organic Chemical Pharmacologic Substance
Preferred_Name	Acridine Carboxamide
UMLS_CUI	C0919282
FDA_UNII_Code	0N3V8R4E13
Contributing_Source	FDA
ALT_DEFINITION	A substance being studied in the treatment of cancer. It is a type of topoisomerase inhibitor.NCI-GLOSS
PDQ_Open_Trial_Search_ID	37776
PDQ_Closed_Trial_Search_ID	37776
Legacy_Concept_Name	Acridine_Carboxamide
FULL_SYN	DACAPTNCI-GLOSSCDR0000044885 DACAABNCI acridine carboxamidePTNCI-GLOSSCDR0000044849 N-(2-(Dimehtylamino)ethyl)acridine-4-carboxamideSNNCI XR5000CNNCI NSC-601316PTFDA0N3V8R4E13 SN 22995CNNCI Acridine CarboxamidePTNCI
DEFINITION	A tricyclic acridine-based (or carboxamide-based) drug with dual topoisomerase inhibitor and potential antineoplastic activities. Acridine carboxamide inhibits both topoisomerases I and II and intercalates into DNA, resulting in DNA damage, the disruption of DNA repair and replication, the inhibition of RNA and protein synthesis, and cell death.NCI
code	C2203
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0335154

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