About: Diarylsulfonylurea Compound     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Diarylsulfonylurea Compound
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Structurally
Preferred_Name
  • Diarylsulfonylurea Compound
UMLS_CUI
  • C1511894
Legacy_Concept_Name
  • Diarylsulfonylurea_Compound
FULL_SYN
  • Diarylsulfonylurea CompoundPTNCI
  • DiarylsulfonylureasSYNCI
DEFINITION
  • A sulfonylurea compound containing aryl groups with potential antineoplastic activity. Originally developed as herbicides, diarylsulfonylureas have shown a broad spectrum of antitumor activity in vivo. The precise mechanism of antitumor action has not yet been elucidated, however, certain diarylsulfonylurea compounds have been shown in preliminary studies to exert antimitotic effects through their inhibition of tubulin polymerization, and others have been shown to be effective antitumor agents in animal models by the mechanism of uncoupling mitochondrial oxidative phosphorylation.NCI
code
  • C2186
is rdfs:subClassOf of
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