About: Gastrin/Cholecystokinin Type B Receptor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gastrin/Cholecystokinin Type B Receptor
equivalentClass
OMIM_Number
  • 118445
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Gastrin/Cholecystokinin Type B Receptor
UMLS_CUI
  • C0248266
Legacy_Concept_Name
  • Cholecystokinin-B_Receptor
FULL_SYN
  • CCKBRSYNCI
  • CCK-B ReceptorSYNCI
  • Cholecystokinin B ReceptorSYNCI
  • GASRSYNCI
  • CCKRBSYNCI
  • CCK-BRSYNCI
  • Gastrin/Cholecystokinin Type B ReceptorPTNCI
  • Cholecystokinin Type B ReceptorSYNCI
Swiss_Prot
  • P32239
DEFINITION
  • Gastrin/cholecystokinin type B receptor (447 aa, 48 kD) is a cell division process protein that is encoded by the human CCKBR gene and has roles in regulation of cell proliferation, feeding behavior, sensory perception, and digestion.NCI
DesignNote
  • Type B (gastrin) receptors of the cholecystokinin (CCK) family are found principally in the CNS and the gastrointestinal tract. In the CNS, they regulate anxiety, arousal, neuroleptic activity, and opiate-induced analgesia. Outside the CNS, they regulate gastric acid secretion and may play a role in gastrointestinal motility and growth of normal and neoplastic gastrointestinal tissue. Cholecystokinin B Receptor (CCKBR), encoded by the CCKBR gene, is a G protein-coupled receptor for gastrin and cholecystokinin. It activates a second messenger system involving phosphatidylinositol turnover and intracellular calcium mobilization. CCKBR can selectively be blocked by nonpeptide benzodiazepine-based antagonists. A single amino acid, valine-319, is critical in determining the binding affinity for these nonpeptide antagonists. Variability in the aliphatic side chain of the amino acid in position 319 confers antagonist specificity. (NCI)
code
  • C21598
sameAs
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