About: 26S Proteasome-Associated UCH Interacting Protein 1     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • 26S Proteasome-Associated UCH Interacting Protein 1
rdfs:subClassOf
OMIM_Number
  • 300370
GenBank_Accession_Number
  • NM_007205
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • 26S Proteasome-Associated UCH Interacting Protein 1
OLD_PARENT
  • Ligand_Binding_Protein
OLD_KIND
  • Gene_Product_Kind
OLD_ROLE
  • Gene_Product_Encoded_by_Gene|TREX2_Gene
  • Gene_Product_Has_Biochemical_Function|Hydrolase
  • Gene_Product_Has_Organism_Source|Human
  • Gene_Product_Plays_Role_In_Biological_Process|Ubiquitination
OLD_STATE
  • Defined
Concept_Status
  • Retired_Concept
FULL_SYN
  • Three Prime Repair Exonuclease 2 Isoform UIP1SYNCI
  • UIP1SYNCI
  • TREX2SYNCI
  • XQ28ORFSYNCI
  • 26S Proteasome-Associated UCH Interacting Protein 1PTNCI
DEFINITION
  • Alternative splicing of the TREX2 gene results in five transcript variants. 26S Proteasome-Associated UCH Interacting Protein 1 results from use of a different open reading frame, producing a protein structurally unrelated to the other isoforms of Three Prime Repair Exonuclease 2 also encoded by the same gene. This protein interacts with ubiquitin C-terminal hydrolase 37, which may edit polyubiquitin chains on ubiquitinated substrates. The physiological role of Ubiquitin C-terminal Hydrolases (UCH) is to hydrolyze C-terminal esters and amides of ubiquitin and to generate free monomeric ubiquitin from ubiquitin proproteins, but not to deubiquitinate ubiquitin-protein conjugates or disassemble polyubiquitin chains. (From PubMed and NCI)NCI
code
  • C21560
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