About: Gamma-Glutamylcysteine Synthetase Inhibitor     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Gamma-Glutamylcysteine Synthetase Inhibitor
rdfs:subClassOf
Semantic_Type
  • Chemical Viewed Functionally
Preferred_Name
  • Gamma-Glutamylcysteine Synthetase Inhibitor
UMLS_CUI
  • C1517431
Legacy_Concept_Name
  • Gamma-Glutamylcysteine_Synthetase_Inhibitor
FULL_SYN
  • Glutathione Synthesis InhibitorsSYNCI
  • Gamma-Glutamylcysteine Synthetase InhibitorPTNCI
  • Glutamate-cysteine Ligase InhibitorSYNCI
  • GCS InhibitorsSYNCI
DEFINITION
  • Any substance that inhibits glutamate-cysteine ligase (gamma-glutamylcysteine synthetase), an enzyme that catalyzes the ATP-dependent condensation of cysteine and glutamate to form the dipeptide gamma-glutamylcysteine, the rate-limiting step in the biosynthesis of glutathione. Since glutathione is critical in protecting cells against oxidative stress, its depletion results in free radical-induced apoptosis.NCI
code
  • C2130
is rdf:first of
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