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AttributesValues
rdf:type
rdfs:label
  • Negative Regulation of G1 to S Transition
rdfs:subClassOf
Semantic_Type
  • Phenomenon or Process
Preferred_Name
  • Negative Regulation of G1 to S Transition
UMLS_CUI
  • C1517339
Legacy_Concept_Name
  • G1-S_Arrest
FULL_SYN
  • G1-S ArrestSYNCI
  • G1/S ArrestSYNCI
  • Negative Regulation of G1 to S TransitionPTNCI
DEFINITION
  • G1-S Arrest consists of cellular biochemical mechanisms, responsive to diverse governing conditions (DNA damage, contact inhibition, growth factors, etc.), that control cellular commitment at the G1 restriction point to DNA replication and the proliferative cycle. G1 to S is controlled by de/phosphorylated cyclin/CDK complexes. During G1, cycD/CDK phosphorylation of Rb/HDAC repressor permits E2F/DP1 transcription of genes that promote the G1/S switch and DNA replication. p53 induces p21 inhibition of cycD/CDK; Mdm2 inhibits p53/p21. TGF-b induces p15 inhibition of cycD/CDK. cAMP induces p27 inhibition of cycD/CDK. GSK3b induction of cycD degradation, and INK4, Kip, and Cdc25A regulate cycD/CDK activity.NCI
code
  • C21230
is someValuesFrom of
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