About: Calcium Binding Protein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • Calcium Binding Protein
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • Calcium Binding Protein
UMLS_CUI
  • C0006732
Legacy_Concept_Name
  • Calcium_Binding_Protein
FULL_SYN
  • Calcium Binding ProteinPTNCI
DEFINITION
  • Calcium Binding Proteins typically belong to the same evolutionary family and often share an EF-hand calcium-binding domain that consists of a 12 residue loop flanked on both sides by a 12 residue alpha-helical domain; the calcium ion is coordinated with oxygen of Glu or Asp residues in a pentagonal bipyramidal configuration. Reversible binding of calcium with proteins often supports protein structure or induces an alteration of protein activity in enzymatic or cell signaling cascades. Calcium is essential for maintenance of a normal heartbeat and for normal cell functions. It also plays a role in blood coagulation and in many enzymatic processes.NCI
code
  • C21214
sameAs
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