About: TNF Receptor Family Gene     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • TNF Receptor Family Gene
rdfs:subClassOf
Semantic_Type
  • Gene or Genome
Preferred_Name
  • TNF Receptor Family Gene
UMLS_CUI
  • C1336652
Legacy_Concept_Name
  • TNF_Receptor_Family_Gene
FULL_SYN
  • TNFRSF GeneSYNCI
  • TNF Receptor Family GenePTNCI
  • Tumor Necrosis Factor Receptor Superfamily GeneSYNCI
  • Tumor Necrosis Factor Receptor Family GeneSYNCI
DEFINITION
  • Human TNF Receptor Family Genes encode transmembrane receptor proteins regulated by TNF Family ligands. TNF receptors typically contain intracellular death domains involved in the formation of a signal transducing death-inducing complex that includes FADD and caspases that trigger an apoptotic caspase cascade. Some TNF receptors can activate NF-Kappa-B, MAPK3/ERK1, MAPK8/JNK, BIRC1, BIRC2, BAG4/SODD, TRADD, or TRAF2 and transduce inflammation or anti-apoptotic proliferating signals. Some TNF Family Receptors act as competitive decoy receptors in bone resorption or suppress FasL- and LIGHT-mediated cell death. (NCI)NCI
code
  • C21165
is rdfs:subClassOf of
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