About: Rho Guanine Nucleotide Exchange Factor 1

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Rho Guanine Nucleotide Exchange Factor 1
equivalentClass	nodeID://b638105
OMIM_Number	601855
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	Rho Guanine Nucleotide Exchange Factor 1
UMLS_CUI	C0606872
Legacy_Concept_Name	Rho_Guanine_Nucleotide_Exchange_Factor-1
FULL_SYN	ARHGEF1SYNCI Rho Guanine Nucleotide Exchange Factor 1PTNCI Rho GEF 1SYNCI
Swiss_Prot	Q92888
DEFINITION	Ubiquitously expressed by human ARHGEF1 Gene as alternative isoforms 1 (912-aa, 102-kD) and 2 (879-aa), cytoplasmic Rho Guanine Nucleotide Exchange Factor 1 contains a (homooligomerizing) coiled coil region, a DH domain, a PH domain, and an RGSL domain (necessary for GAP activity). Responsive to extracellular stimuli acting through GPCRs, ARHGEF1 may complex with G proteins and regulates cell cycle and cell proliferation activity. Phosphorylated by PKCA and translocated to the plasma membrane by stimulation, ARHGEF1 seems to regulate RHOA GTPase signal transduction as a GEF and GNA12 and GNA13 (RGS domain interaction) as a GAP. ARHGEF1 GEF activity is inhibited by binding to activated GNA12. (NCI)NCI
code	C20942
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0065423

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