About: SWI/SNF Family Complex

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Attributes	Values
rdf:type	Class
rdfs:label	SWI/SNF Family Complex
rdfs:subClassOf	Protein or Riboprotein Complex
Semantic_Type	Amino Acid, Peptide, or Protein
Preferred_Name	SWI/SNF Family Complex
UMLS_CUI	C1335883
Legacy_Concept_Name	SWI-SNF_Family_Complex
FULL_SYN	SWI/SNF Family ComplexPTNCI Mating Type Switching/Sucrose Nonfermenting ProteinSYNCI
DEFINITION	Involved in transcriptional activation of numerous genes, yeast SWI2/SNF2 contains a highly conserved domain among helicases required for transcriptional activity. Mammalian SWI/SNF complexes are ATP-dependent chromatin remodeling enzymes implicated in regulation of gene expression, cell cycle control, and oncogenesis. The SWI/SNF complex is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. The complex contains an ATP-dependent nucleosome disruption activity that can lead to enhanced binding of transcription factors. During mitosis, the human protein is phosphorylated, excluded from condensed chromosomes, and the protein level is strongly reduced. (from OMIM 600014 and NCI)NCI
code	C20591
is someValuesFrom of	nodeID://b649193 nodeID://b710559 nodeID://b710570 nodeID://b711399 nodeID://b711412 nodeID://b711414 nodeID://b711415 nodeID://b711416 nodeID://b711417

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