About: Interleukin-12

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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

Attributes	Values
rdf:type	Class
rdfs:label	Interleukin-12
rdfs:subClassOf	Protein or Riboprotein Complex nodeID://b683498 nodeID://b683499 nodeID://b683500 nodeID://b683501 nodeID://b683502 nodeID://b683503 nodeID://b683504
Semantic_Type	Immunologic Factor
Preferred_Name	Interleukin-12
UMLS_CUI	C0123759
Legacy_Concept_Name	Interleukin-12
FULL_SYN	Interleukin 12SYNCI Interleukin-12PTNCI IL12SYNCI CLMFSYNCI NKSFSYNCI IL-12SYNCI Natural Killer Cell Stimulatory FactorSYNCI Cytotoxic Lymphocyte Maturation FactorSYNCI IL-12p70SYNCI IL-12 p70SYNCI
DEFINITION	Exhibiting a broad range of biological activities on T and natural killer cells, Interleukin-12 is a disulfide-bonded heterodimeric cytokine composed of a 35-kD IL12A subunit (IL-6 Superfamily) and a 40-kDa IL12B subunit (Type I Cytokine Receptor 3 Family). IL12 stimulates T-cell-independent production of IFN-gamma by PBMCs, enhances NK cell lytic activity, acts as a growth factor for T- and NK-cells, and is important for Th1 and Th2 cell differentiation. Lymphocyte responses to IL12 require NOS2A and are mediated by STAT4 activator of transcription. (NCI)NCI
code	C20514
sameAs	Interleukin-12
http://linked.open...y/mesh/hasConcept	http://linked.opendata.cz/resource/mesh/concept/M0027969
is someValuesFrom of	nodeID://b683526 nodeID://b683536
is sameAs of	Interleukin-12

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