About: Interleukin-10     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Interleukin-10
equivalentClass
OMIM_Number
  • 124092
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Biologically Active Substance
  • Immunologic Factor
Preferred_Name
  • Interleukin-10
UMLS_CUI
  • C0085295
ALT_DEFINITION
  • Factor that is a coregulator of mast cell growth. It is produced by T-cells and B-cells and shows extensive homology with the Epstein-Barr virus BCRFI gene.MSH2002_06_01
  • One of a group of related proteins made by leukocytes (white blood cells) and other cells in the body. IL-10 is made by activated macrophages and by some T lymphocytes. It reduces inflammation by blocking production of cytokines by immune cells. IL-10 also increases antibody production by plasma cells and helps them live longer. IL-10 made in the laboratory is used as a biological response modifier to boost the immune system. It is a type of cytokine.NCI-GLOSS
Legacy_Concept_Name
  • Interleukin-10
FULL_SYN
  • Interleukin 10 PrecursorSYNCI
  • IL-10PTNCI-GLOSSCDR0000682069
  • Interleukin 10SYNCI
  • Interleukin-10PTNCI
  • Cytokine Synthesis Inhibitory FactorSYNCI
  • IL10SYNCI
  • CSIFABNCI
  • TGIFSYNCI
  • IL-10SYNCI
  • IL10ASYNCI
  • interleukin-10PTNCI-GLOSSCDR0000557293
  • CSIF-10SYNCI
Swiss_Prot
  • P22301
DEFINITION
  • Expressed primarily in monocytes and less in lymphocytes by human IL10 Gene, Interleukin-10 is a cytokine with pleiotropic effects in immunoregulation and inflammation. It down-regulates expression of Th1 cytokines, MHC class II antigens, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Studies in mice suggest that this cytokine as an essential immunoregulator in the intestinal tract. (From LocusLink)NCI
code
  • C20512
sameAs
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