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An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Indibulin
rdfs:subClassOf
Concept_In_Subset
Semantic_Type
  • Pharmacologic Substance
Preferred_Name
  • Indibulin
UMLS_CUI
  • C0963638
CAS_Registry
  • 204205-90-3
FDA_UNII_Code
  • 80K4H2RB8P
Contributing_Source
  • FDA
PDQ_Open_Trial_Search_ID
  • 587341
PDQ_Closed_Trial_Search_ID
  • 587341
Chemical_Formula
  • C22H16ClN3O2
Legacy_Concept_Name
  • D_24851
FULL_SYN
  • INDIBULINPTFDA80K4H2RB8P
  • D 24851CNNCI
  • D-24851CNNCI
  • ZIO-301CNNCI
  • IndibulinPTNCI
  • N-(pyridin-4-yl)-[1-(4-chlorbenzyl)-indol-3-yl]-glyoxyl-amid)SNNCI
DEFINITION
  • A synthetic small molecule with antimitotic and potential antineoplastic activities. Indibulin binds to a site on tubulin that is different from taxane- or Vinca alkaloid-binding sites, destabilizing tubulin polymerization and inducing tumor cell cycle arrest and apoptosis. This agent has been shown to be active against multidrug-resistant (MDR) and taxane- resistant tumor cell lines.NCI
code
  • C2049
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