About: Epidermal Growth Factor     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Epidermal Growth Factor
equivalentClass
OMIM_Number
  • 131530
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Hormone
Preferred_Name
  • Epidermal Growth Factor
UMLS_CUI
  • C0242275
ALT_DEFINITION
  • A 6 kD polypeptide growth factor initially discovered in mouse submaxillary glands. Human epidermal growth factor was originally isolated from urine based on its ability to inhibit gastric secretion and called urogastrone. EPIDERMAL GROWTH FACTOR exerts a wide variety of biological effects including the promotion of proliferation and differentiation of mesenchymal and epithelial cells.MSH2002_06_01
  • A protein made by many cells in the body and by some types of tumors. It causes cells to grow and differentiate (become more specialized). It is a type of growth factor and a type of cytokine.NCI-GLOSS
Legacy_Concept_Name
  • Epidermal_Growth_Factor
FULL_SYN
  • EGFPTNCI-GLOSSCDR0000653115
  • Anthelone USYNCI
  • UrogastroneSYNCI
  • Epidermal Growth FactorPTNCI
  • EGFSYNCI
  • Human Urinary Gastric InhibitorSYNCI
  • epidermal growth factorPTNCI-GLOSSCDR0000653114
Swiss_Prot
  • P01133
DEFINITION
  • Epidermal growth factor affects the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. EGF is synthesized as a large protein precursor of 1,168 amino acids. Mature EGF is a single-chain polypeptide consisting of 53 amino acids and having a molecular mass of about 6,000 daltons. (OMIM)NCI
  • Epidermal Growth Factor, encoded by the EGF gene, has a profound effect on the differentiation of specific cells in vivo and is a potent mitogenic factor for a variety of cultured cells of both ectodermal and mesodermal origin. The EGF precursor is believed to exist as a membrane-bound molecule that is proteolytically cleaved to generate the 53-amino acid peptide hormone that stimulates cells to divide. (From LocusLink)NCI
code
  • C20425
sameAs
http://linked.open...y/mesh/hasConcept
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