About: Skeletal Development

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Attributes	Values
rdf:type	Class
rdfs:label	Skeletal Development
rdfs:subClassOf	Organogenesis nodeID://b712656 nodeID://b712657
Semantic_Type	Organ or Tissue Function
Preferred_Name	Skeletal Development
UMLS_CUI	C1160401
Legacy_Concept_Name	Skeletal_Development
FULL_SYN	Skeletal DevelopmentPTNCI
DEFINITION	Human Skeletal Development involves growth and differentiation of axial, limb, and cranial elements of the skeletal system. Axial vertebrae and ribs derive from cartilage precursors of the paired segmented paraxial mesodermal somite sclerotomes. Interdependent positional signaling by the apical ectodermal ridge, the posterior mesenchyme zone of polarizing activity, and the non ridge ectoderm coordinate limb bud outgrowth and patterning by migrated lateral plate mesoderm and somite cells. Proximal-distal differentiating mesenchymal cells condense to form the limb skeletal primordia. The skull forms by direct ossification of, or cartilage condensation from neural crest-derived, ectomesenchyme.NCI
code	C20138
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