About: RET Oncoprotein     Goto   Sponge   NotDistinct   Permalink

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AttributesValues
rdf:type
rdfs:label
  • RET Oncoprotein
rdfs:subClassOf
OMIM_Number
  • 164761
Semantic_Type
  • Amino Acid, Peptide, or Protein
Preferred_Name
  • RET Oncoprotein
UMLS_CUI
  • C1335613
Legacy_Concept_Name
  • RET_Oncoprotein
FULL_SYN
  • RET OncoproteinPTNCI
Swiss_Prot
  • P07949
DEFINITION
  • Human RET Oncoprotein is a product of mutated variants (Oncogene RET) of RET Gene, which encodes Tyrosine-Protein Kinase Receptor RET, a type I membrane protein receptor for Glial Cell Line-Derived with an extracellular cadherin-like domain and important in neural crest development. Some oncogenic RET point mutations cause constitutive kinase activation. PTC1 oncogene involves fusion of RET kinase to the H4 dimerization leucine zipper. In PTC6, RET is fused to the N-terminal part of Transcriptional Intermediary Factor-1-Alpha. In PTC7, RET is fused to a C-terminal part of TIF1-Gamma. Oncogenic RET mutations are associated with Hirschsprung's disease, Multiple Endocrine Neoplasia, pheochromocytoma, hyperparathyroidism and medullary thyroid cancer. RET Oncoprotein disrupts normal cell function.NCI
code
  • C19954
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