About: Gcn5p     Goto   Sponge   NotDistinct   Permalink

An Entity of Type : owl:Class, within Data Space : linked.opendata.cz associated with source document(s)

AttributesValues
rdf:type
rdfs:label
  • Gcn5p
rdfs:subClassOf
Semantic_Type
  • Amino Acid, Peptide, or Protein
  • Enzyme
Preferred_Name
  • Gcn5p
UMLS_CUI
  • C1171569
Legacy_Concept_Name
  • Gcn5p
FULL_SYN
  • Gcn5pPTNCI
DEFINITION
  • Gcn5p is a transcriptional coactivator required for correct expression of various genes in yeast. Several transcriptional regulators, including Gcn5p, possess intrinsic histone acetyltransferase (HAT) activity in vitro.NCI
DesignNote
  • Containing a bromodomain, Gcn5p is a general transcriptional activator operating in concert with other DNA-binding transcriptional activators, such as GCN4 or HAP2/3/4. Gcn5p functions in the SAGA adaptor/HAT complex as a nucleosomal histone acetyltransferase to promote transcriptional activation. HAT Gcn5p also functions as a heterodimer with ada2 as part of the ADA adaptor/HAT complex that consists of hfi1/ada1, ada2, ada3, spt20/ada5 and gcn5. It has a strong preference for Lysine 14 of H3 and a lower preference for Lysines 8, 16 of H4. (from SWISS-PROT Q03330, SGD S0003484, LocusLink 2648)
code
  • C19894
http://linked.open...y/mesh/hasConcept
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